No Mail Flow

Hello,

Can someone please advise...

There were no changes that I was aware of in my lab but I now have no mail flow. When testing with Exchange Connectivity Tester I get:

 The server returned status code 451 - Error in processing. The server response was: 4.7.0 Temporary server error. Please try again later. PRX5
Exception details:
Message: Error in processing. The server response was: 4.7.0 Temporary server error. Please try again later. PRX5
Type: System.Net.Mail.SmtpException
Stack trace:
at System.Net.Mail.DataStopCommand.CheckResponse(SmtpStatusCode statusCode, String serverResponse)
at System.Net.Mail.DataStopCommand.Send(SmtpConnection conn)
at System.Net.Mail.SmtpClient.Send(MailMessage message)
at Microsoft.Exchange.Tools.ExRca.Tests.SmtpMessageTest.PerformTestReally()
Elapsed Time: 24526 ms. 

I am running a single Exchange 2013 Server on a VM!

There seem to be plenty of resources to run it and autodiscovery works, Outlook connects but no mail flows and external mail bounces!

Can anyone advise where I am going wrong?