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451 4.7.0 Temporary server error. Please try again later. PRX5

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I've noticed that on occassion when I connect to my Exchange 2013 CU 1 server, the server will respond with "451 4.7.0 Temporary server error. Please try again later. PRX5" after I submit an e-mail for delivery.  It accepts the sender, verifies the recipient, asks for data and fails only upon submission.  Trying again right after the failure usually takes care of the problem what that's not a fix.  What's causing the problem? Anyone else seen this?

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